Peer-Reviewed Journal Details
Mandatory Fields
Singh, I;Heaney, F
2011
January
Chemical Communications
Solid phase strain promoted "click" modification of DNA via [3+2]-nitrile oxide-cyclooctyne cycloadditions
Published
36 ()
Optional Fields
1,3-DIPOLAR CYCLOADDITIONS CHEMISTRY FUNCTIONALIZATION DELIVERY SYSTEMS
47
2706
2708
Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne-nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.
CAMBRIDGE
1359-7345
10.1039/c0cc03985c
Grant Details