Peer-Reviewed Journal Details
Mandatory Fields
Sullivan, M;Kia, AFA;Long, M;Walsh, M;Kavanagh, K;McClean, S;Creaven, BS
2014
January
Polyhedron
Isolation and characterisation of silver(I) complexes of substituted coumarin-4-carboxylates which are effective against Pseudomonas aeruginosa biofilms
Published
16 ()
Optional Fields
RAY CRYSTAL-STRUCTURES ANTIMICROBIAL ACTIVITY COUMARIN-3-CARBOXYLIC ACID ANTIBACTERIAL ACTIVITY SIMPLE COUMARINS METAL-COMPLEXES WOUND CARE IN-VITRO COPPER(II) RESISTANCE
67
549
559
A novel series of coumarin-4-carboxylate ligands (2a-2l), their Ag(I) complexes (3a-3l) together with a number of their phenanthroline adducts (4d, 41 and 4g) have been synthesised and characterised. The ligands were prepared by either acid or base hydrolysis of their corresponding esters or by demethylation of a methylated acid derivative. The esters (1a-1i) were synthesised by an aromatic electrophilic substitution reaction between the conjugate base of substituted phenols and a vinyltriphenylphosphonium salt. The novel series of Ag(I) carboxylate complexes were prepared by reaction of silver nitrate with the coumarin ligands in aqueous/alcohol solution. The Ag(I) phenanthroline adducts were prepared by reaction of the Ag(I) complex with 1,10-phenanthroline in aqueous/alcohol solution. A selection of complexes were screened for their in vitro antibacterial activity against Pseudomonas aeruginosa grown planktonically or as a biofilm as well as a number of other clinically important strains, Escherichia coli, MRSA and Staphylococcus aureus. The activity against the P. aeruginosa biofilm was found to be significantly greater than against the planktonic bacteria. (C) 2013 Elsevier Ltd. All rights reserved.
OXFORD
0277-5387
10.1016/j.poly.2013.09.042
Grant Details