Peer-Reviewed Journal Details
Mandatory Fields
Algay, V;O'Sullivan, J;Heaney, F
2014
April
European Journal of Organic Chemistry
C-3 beta-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC)
Published
4 ()
Optional Fields
CLICK CHEMISTRY COPPER(I)-CATALYZED SYNTHESIS EFFICIENT SYNTHESIS TERMINAL ALKYNES SOLID-PHASE SIDE-CHAIN DELIVERY DERIVATIVES ANALOGS NANOPARTICLES
2014
2522
2532
Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol-biomolecule conjugates.
WEINHEIM
1434-193X
10.1002/ejoc.201301822
Grant Details