Peer-Reviewed Journal Details
Mandatory Fields
McGinley, J;McCann, M;Ni, KJ;Tallon, T;Kavanagh, K;Devereux, M;Ma, XM;McKee, V
2013
May
Polyhedron
Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities
Published
16 ()
Optional Fields
SILVER(I) COMPLEXES METAL-COMPLEXES IN-VITRO ACID 1,10-PHENANTHROLINE-5,6-DIONE EFFICACY DRUG
55
169
178
1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldehyde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo, towards Galleria mellonella. Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro, against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity. (C) 2013 Elsevier Ltd. All rights reserved.
OXFORD
0277-5387
10.1016/j.poly.2013.03.023
Grant Details