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Mandatory Fields
Reviews
Johnson, G;Ferrini, A;Dolan, SK;Nolan, T;Agrawal, S;Doyle, S;Bustin, SA
2014
March
Biomarkers for invasive aspergillosis: the challenges continue
Published
1
12 ()
Optional Fields
BRONCHOALVEOLAR LAVAGE FLUID REAL-TIME PCR FLIGHT MASS-SPECTROMETRY GALACTOMANNAN ENZYME-IMMUNOASSAY EXHALED BREATH CONDENSATE DESORPTION IONIZATION-TIME POLYMERASE-CHAIN-REACTION BETA-D-GLUCAN SEQUENCE-BASED AMPLIFICATION ORGAN TRANSPLANT RECIPIENTS
The incidence of invasive aspergillosis (IA), an opportunistic infection in immunocompromised individuals, is rising, but its early diagnosis remains challenging and treatment options are limited. Hence there is an urgent need to improve existing diagnostic procedures as well as develop novel approaches. The clinical usefulness of galactomannan and -d-glucan, widely used assays detecting cell-wall antigens of Aspergillus, is unclear and depends on clinicians' awareness of their practical limitations. This leaves room for new methods that utilise genomic, proteomic and metabolomics approaches as well as novel detection procedures, for example point-of-care lateral-flow devices. Each of these strategies has its own limitations and it is likely that a combination of methods will be required to achieve optimal performance for the diagnosis of IA and subsequent appropriate patient management.
LONDON
FUTURE MEDICINE LTD
1752-0363
429
451
10.2217/BMM.13.129
Grant Details