Peer-Reviewed Journal Details
Mandatory Fields
Algay, V;Singh, I;Heaney, F
2010
January
Organic and Biomolecular Chemistry
Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide-alkyne 1,3-dipolar cycloaddition
Published
24 ()
Optional Fields
MICROWAVE-ASSISTED SYNTHESIS ONE-POT SYNTHESIS C-NUCLEOSIDES ISOXAZOLE REPLACEMENT CHEMISTRY DESIGN ESTERS
8
391
397
An efficient, catalyst free, 1,3-dipolar cycloaddition strategy to conjugate nucleosides and nucleotides with isoxazoles under atmospheric conditions and in an aqueous environment is reported. The protocol involves chloramine-T as a practical reagent to induce in situ nitrile oxide formation and the alkyne partner is attached to the sugar residue or the nucleobase. The reactions are regiospecific, fast and high yielding.
CAMBRIDGE
1477-0520
10.1039/b917450h
Grant Details