Peer-Reviewed Journal Details
Mandatory Fields
Gavin, DP;Stephens, JC
2013
January
Arkivoc
Selective Michael additions to alkylidenemalonates using thiourea-based bifunctional organocatalysts
Published
3 ()
Optional Fields
ENANTIOSELECTIVE CONJUGATE ADDITION ALDEHYDES SULFONES NITROALKANES NITROOLEFINS DERIVATIVES ACTIVATION CHALCONES KETONES
76
87
Bifunctional thiourea catalysts have been found to be excellent promoters of the challenging Michael addition to alkylidenemalonates giving high yields of up to 99%. Substrate structure was important for enantiodiscrimination, with aryl alkylidenemalonate acceptors furnishing products with ee values of up to 73%.
GAINESVILLE
1551-7004
Grant Details