Peer-Reviewed Journal Details
Mandatory Fields
English, K;Wood, KJ
2013
May
Cold Spring Harbor perspectives in medicine
Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance
Published
52 ()
Optional Fields
REGULATORY T-CELLS VERSUS-HOST-DISEASE SYSTEMIC-LUPUS-ERYTHEMATOSUS ISCHEMIA-REPERFUSION INJURY CHRONIC KIDNEY INJURY TOLL-LIKE RECEPTORS STEM-CELLS DENDRITIC CELLS IN-VIVO LYMPHOCYTE-PROLIFERATION
3
Mesenchymal stromal cells (MSCs) have recently emerged as promising candidates for cell-based immunotherapy in solid organ transplantation (SOT). In addition to immune modulation, MSCs possess proreparative properties and preclinical studies indicate that MSCs have the capacity to prolong graft survival and in some cases induce tolerance. Currently, the application of MSCs in SOT is being evaluated in phase I/II clinical trials. Whereas the mechanisms of action used by MSC immunomodulation have been somewhat elucidated in vitro, the data from preclinical transplant models have been unclear. Furthermore, the optimal timing, dose, and route of administration remain to be elucidated. Importantly, MSCs have the ability to sense their environment, which may influence their function. In this article, we discuss the impact of the local microenvironment on MSCs and the mechanisms of MSC immunomodulation in the setting of SOT.
COLD SPRING HARBOR
2157-1422
10.1101/cshperspect.a015560
Grant Details