Peer-Reviewed Journal Details
Mandatory Fields
Garcia, MR;Pearlmutter, BA;Wellstead, PE;Middleton, RH
2013
September
PLoS ONE
A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation
Published
8 ()
Optional Fields
SHORT-LATENCY ACTIVATION PARKINSONS-DISEASE SUBTHALAMIC NUCLEUS BASAL GANGLIA CORPUS-CALLOSUM RAT-BRAIN CORTEX POTENTIALS GENERATION MECHANISM
8
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena, and makes a variety of novel predictions.
SAN FRANCISCO
1932-6203
10.1371/journal.pone.0073456
Grant Details