Peer-Reviewed Journal Details
Mandatory Fields
Diviney, M;Fey, D;Commins, S
2013
July
Learning and Memory
Hippocampal contribution to vector model hypothesis during cue-dependent navigation
Published
7 ()
Optional Fields
MORRIS WATER MAZE PATH-INTEGRATION COGNITIVE MAPS SPATIAL MEMORY PLACE CELLS FIMBRIA-FORNIX RATS LESIONS LANDMARK BEHAVIOR
20
367
378
Learning to navigate toward a goal is an essential skill. Place learning is thought to rely on the ability of animals to associate the location of a goal with surrounding environmental cues. Using the Morris water maze, a task popularly used to examine place learning, we demonstrate that distal cues provide animals with distance and directional information. We show how animals use the cues in a visually dependent guidance manner to find the goal. Further, we demonstrate how hippocampal lesions disrupt this learning mechanism. Our results can be explained through the vector model of navigation built on associative learning principles rather than evoking a cognitive map.
COLD SPRING HARBOR
1072-0502
10.1101/lm.029272.112
Grant Details