Peer-Reviewed Journal Details
Mandatory Fields
Reeves, EP;Nagl, M;O'Keeffe, J;Kelly, J;Kavanagh, K
2006
July
Journal of Medical Microbiology
Effect of N-chlorotaurine on Aspergillus, with particular reference to destruction of secreted gliotoxin
Published
9 ()
Optional Fields
PULMONARY ASPERGILLOSIS FUNGAL METABOLITE HYPOCHLOROUS ACID CANDIDA-ALBICANS PHASE-II IN-VITRO FUMIGATUS TOLERABILITY NEUTROPHILS EFFICACY
55
913
918
The fungistatic and fungicidal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated neutrophils, was investigated. Physiological concentrations (75-100 mu M) of NCT showed clear fungicidal activity against a range of Aspergillus isolates. Moreover, killing by NCT was significantly increased in the presence of ammonium chloride, explained by the formation of monochloramine by halogenation of ammonium. One clinical isolate of Aspergillus fumigatus was characterized for the production of the immunosuppressive agent gliotoxin, and NCT was shown to cause destruction of gliotoxin, possibly via reduction of the disulphide bridge. Because of its endogenous nature and its high antifungal activity, NCT appears to be a good choice for topical treatment of Aspergillus infections, and the results of this study further substantiate its therapeutic efficacy.
READING
0022-2615
10.1099/jmm.0.46405-0
Grant Details