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Mandatory Fields
Reviews
Dolan, SK;O'Keeffe, G;Jones, GW;Doyle, S
2015
July
Resistance is not futile: gliotoxin biosynthesis, functionality and utility
Published
1
45 ()
Optional Fields
NONRIBOSOMAL PEPTIDE SYNTHETASE ASPERGILLUS-FUMIGATUS VIRULENCE OXIDATIVE STRESS-RESPONSE FACTOR-KAPPA-B SELF-PROTECTION GENE-CLUSTER STREPTOMYCES-CLAVULIGERUS SACCHAROMYCES-CEREVISIAE INVASIVE ASPERGILLOSIS SECONDARY METABOLISM
Gliotoxin biosynthesis is encoded by the gene cluster in Aspergillus fumigatus. The biosynthesis of gliotoxin is influenced by a suite of transcriptionally-active regulatory proteins and a bis-thiomethyltransferase. A self-protection system against gliotoxin is present in A. fumigatus. Several additional metabolites are also produced via the gliotoxin biosynthetic pathway. Moreover, the biosynthesis of unrelated natural products appears to be influenced either by gliotoxin or by the activity of specific reactions within the biosynthetic pathway. The activity of gliotoxin against animal cells and fungi, often mediated by interference with redox homeostasis or protein modification, is revealing new metabolic interactions within eukaryotic systems. Nature has provided a most useful natural product with which to reveal some of its many molecular secrets.
OXFORD
ELSEVIER SCI LTD
0966-842X
419
428
10.1016/j.tim.2015.02.005
Grant Details