Peer-Reviewed Journal Details
Mandatory Fields
Martiez-Calvo, M;Orange, KN;Elmes, RBP;Poulsen, BL;Williams, DC;Gunnlaugsson, T
2016
January
Nanoscale
Ru(II)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents
Published
20 ()
Optional Fields
RUTHENIUM(II) POLYPYRIDYL COMPLEXES LIGHT-SWITCH BEHAVIOR CANCER-CELLS INORGANIC NANOPARTICLES MAGNETIC NANOPARTICLES SILVER NANOPARTICLES ELECTRON-TRANSFER RU(II) COMPLEXES AU NANOPARTICLES DRUG-DELIVERY
8
563
574
The development of Ru(II) functionalized gold nanoparticles 1-3 center dot AuNP is described. These systems were found to be mono-disperse with a hydrodynamic radius of ca. 15 nm in water but gave rise to the formation of higher order structures in buffered solution. The interaction of 1-3 center dot AuNP with DNA was also studied by spectroscopic and microscopic methods and suggested the formation of large self-assembly structures in solution. The uptake of 1-3 center dot AuNP by cancer cells was studied using both confocal fluorescence as well as transmission electron microscopy (TEM), with the aim of investigating their potential as tools for cellular biology. These systems displaying a non-toxic profile with favourable photophysical properties may have application across various biological fields including diagnostics and therapeutics.
CAMBRIDGE
2040-3364
10.1039/c5nr05598a
Grant Details