Peer-Reviewed Journal Details
Mandatory Fields
Harvey, D;Smith, R;English, K;Mahon, B;Commins, S
2006
May
Physiology and Behavior
Interleukin-10 (IL-10) but not Lipopolysaccharide (LPS) produces increased motor activity and abnormal exploratory patterns while impairing spatial learning in Balb/c mice
Published
15 ()
Optional Fields
OPEN-FIELD BEHAVIOR OBJECT EXPLORATION MUROID RODENTS C57BL/6J MICE RATS HABITUATION PERFORMANCE EXPRESSION ENDOTOXIN LESIONS
87
842
847
Lipopolysaccharide (LPS) is a potent endotoxin, which produces "sickness behaviours" including loss of weight, loss of interest in food and decreased exploration. LPS has also been shown in some studies to cause deficits in various learning and memory abilities, while in others these LPS-induced learning impairments have been attributed to performance-related deficits rather than learning deficits per se. Here, we use the novelty-preference paradigm, a task that minimises performance-related factors such as motivation, in an attempt to extract and examine the effects of LPS on spatial learning. In addition, some studies have indicated that the anti-inflammatory cytokine Interleukin-10 (IL-10) can alleviate some of the symptoms induced by LPS. Here, we also examine the effect of IL-10 on feeding, motor and learning behaviours. We demonstrate that a single injection of LPS does produce a lack of interest in food and weight loss; LPS, however, does not impair habituation in the novelty-preference paradigm. Furthermore, co-injection of IL-10 with LPS does not attenuate the LPS-induced effects of weight loss and lack of food intake. Interestingly, a single injection of IL-10 produces abnormal patterns of exploration, a general increase in activity and abnormal patterns of habituation. (c) 2006 Elsevier Inc. All rights reserved.
OXFORD
0031-9384
10.1016/j.physbeh.2006.03.002
Grant Details