Peer-Reviewed Journal Details
Mandatory Fields
Corcoran, A;Mahon, BP;McParland, P;Davoren, A;Doyle, S
2003
July
Journal of Medical Virology
Ex vivo cytokine responses against parvovirus B19 antigens in previously infected pregnant women
Published
13 ()
Optional Fields
NONIMMUNE HYDROPS-FETALIS CELL APLASIA EXPRESSION TROPHOBLAST ACTIVATION FAILURE DEATH NS1 IGG IMPLANTATION
70
475
480
Parvovirus B19 infection is a significant cause of fetal death. The aim of this study was to investigate the role of maternal immune status in modulating susceptibility to fetal B19 infection. Peripheral blood was obtained from pregnant women (n = 199) with no clinical evidence of recent B19 infection. Evaluation of ex vivo T cell responses from 149/199 individuals showed significantly higher interferon-gamma levels for seropositive individuals following VP1 (268 +/- 36 versus 103 +/- 19 pg/ml; P = 0.003) and VP2 (242 +/- 42 versus 91 +/- 16 pg/ml; P = 0.01) antigen stimulation. Significantly higher levels of interleukin-2 were also observed in seropositive individuals following both VP1 (P = 0.0003) and VP2 (P = 0.0005) stimulation. The observed Th1 cellular response is lower than that documented previously for non-pregnant individuals and strongly suggests that diminution of the maternal antiviral immune response may increase susceptibility to fetal B19 infection. (C) 2003Wiley-Liss, Inc.
NEW YORK
0146-6615
10.1002/jmv.10420
Grant Details