Peer-Reviewed Journal Details
Mandatory Fields
Al-Rawi, N;Kavanagh, K
1999
January
British Journal of Biomedical Science
Characterisation of yeasts implicated in vulvovaginal candidosis in Irish women
Published
19 ()
Optional Fields
VULVO-VAGINAL CANDIDIASIS BUCCAL EPITHELIAL-CELLS PHOSPHOLIPASE-ACTIVITY ALBICANS ADHERENCE VAGINITIS IDENTIFICATION RESISTANCE
56
99
104
High-vaginal swabs were taken from 98 women attending a genitourinary clinic in Dublin city who presented with symptoms of vaginitis. Twenty-eight (28.6%) proved culture-positive for yeasts. Candida albicans was isolated from 26 of the yeast-positive patients and Candida glabrata and Candida tropicalis were isolated from a further two patients. Two patients were colonised by two yeasts simultaneously (C. albicans and Candida lucitaniae, and C. albicans and Candida krusei). Yeasts were characterised on the basis of their adherence ability, extracellular enzyme production and resistance to antifungal agents. All C. albicans isolates demonstrated high adherence abilities to buccal epithelial cells, but produced relatively low levels of phospholipase and acid proteinase. The non-C. albicans isolates demonstrated low levels of adherence, but no extracellular enzyme production was detected. Isolates were most sensitive to the polyenes amphotericin B and nystatin but a large proportion (50%) of C. albicans isolates were resistant to clotrimazole, which is an important agent in the treatment of vulvovaginal candidosis.
LONDON
0967-4845
Grant Details