Peer-Reviewed Journal Details
Mandatory Fields
Freeman, C;Cheallaigh, AN;Heaney, F
2011
October
Tetrahedron
Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry
Published
11 ()
Optional Fields
1,3-DIPOLAR CYCLOADDITION MODIFIED NUCLEOSIDES NITRILE OXIDES MAJOR GROOVE DNA STACKING ALKYNES
67
7860
7865
The versatility of the isoxazole generating nitrile oxide-alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended; in a novel approach isoxazole conjugated oligodeoxyribonucleotides have been constructed by phosphoramidite chemistry of isoxazole derivatives previously generated by nitrile oxide-alkyne click chemistry. The conjugation involves manual solid phase synthesis at room temperature in aqueous ethanol and proceeds in high yield. (C) 2011 Elsevier Ltd. All rights reserved.
OXFORD
0040-4020
10.1016/j.tet.2011.06.096
Grant Details