Peer-Reviewed Journal Details
Mandatory Fields
McCann, M;McGinley, J;Ni, K;O'Connor, M;Kavanagh, K;Mckee, V;Colleran, J;Devereux, M;Gathergood, N;Barron, N;Prisecaru, A;Kellett, A
2013
January
Chemical Communications
A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction
Published
27 ()
Optional Fields
RAY CRYSTAL-STRUCTURE ROOM-TEMPERATURE COMPLEXES 1,10-PHENANTHROLINE DERIVATIVES INTERCALATION CLEAVAGE MODES
49
2341
2343
1,10-Phenanthroline-5,6-dione and L-tyrosine methyl ester react to form phenanthroline-oxazine (PDT) from which [Cu(PDT)(2)](ClO4)(2) and [Ag(PDT)(2)]ClO4 center dot 2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)(2)](2+), the [Cu(PDT)(2)](2+) complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
CAMBRIDGE
1359-7345
10.1039/c3cc38710k
Grant Details