Peer-Reviewed Journal Details
Mandatory Fields
McCann, M;Curran, R;Ben-Shoshan, M;McKee, V;Devereux, M;Kavanagh, K;Kellett, A
2013
June
Polyhedron
Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles
Published
26 ()
Optional Fields
GALLERIA-MELLONELLA
56
180
188
[Ag-2(9-aca)(2)] (9-acaH = 9-anthracenecarboxylic acid) interacts with DMSO and a selection of substituted imidazoles giving [Ag-4(DMSO)(4)(9-aca)(4)] (1), [Ag(2-Me-imH)(2)(9-aca)] (2), [Ag(4-Ph-imH)(2)(9-aca)] (3), [Ag(2-Mebenz-imH)2(()9-aca)] (4), [Ag(2-Mebenz-im)] (6), [Ag(Benz-im)] (7), [Ag(2-Ph-im)] (8) and [Ag(4,5-CN-im)] (9) (2-Me-imH = 2-methylimidazole; 4-Ph-imH = 4-phenylimidazole; 2-Mebenz-imH = 2-methylbenzimidazole; Benz-imH = benzimidazole; 2-Ph-imH = 2-phenylbenzimidazole; 4,5-CN-imH = 4,5-dicyanoimidazole). In the carboxylate/imidazole complexes 2-4, the imidazole ligand is in the neutral form, whilst in complexes 6-9 the imidazolate ligand is deprotonated and no carboxylate ligand is present. Attempted recrystallization of 4 from EtOH gives the metal-free, imidazolium salt, 2-Mebenz-imH(2))(9-aca)center dot H2O (5). The X-ray crystal structures of complexes 1 and 2 and the salt 5 were determined. Antimicrobial screening showed that the Ag(l) complexes were substantially more active against the fungus Candida albicans than the bacterial species, methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Some of the complexes offer a good prognosis for Galleria mellonella (larvae of the greater wax moth) infected with a lethal dose of C. albicans cells. (C) 2013 Elsevier Ltd. All rights reserved.
OXFORD
0277-5387
10.1016/j.poly.2013.03.057
Grant Details