Peer-Reviewed Journal Details
Mandatory Fields
Pearlmutter, BA;Houghton, CJ
2009
June
Neural Computation
A New Hypothesis for Sleep: Tuning for Criticality
Published
22 ()
Optional Fields
NEURAL-NETWORKS REM-SLEEP NEURONAL AVALANCHES PARADOXICAL SLEEP HELMHOLTZ MACHINE MEMORY STATES TIME DEPRIVATION WAKEFULNESS
21
1622
1641
We propose that the critical function of sleep is to prevent uncontrolled neuronal feedback while allowing rapid responses and prolonged retention of short-term memories. Through learning, the brain is tuned to react optimally to environmental challenges. Optimal behavior often requires rapid responses and the prolonged retention of short-term memories. At a neuronal level, these correspond to recurrent activity in local networks. Unfortunately, when a network exhibits recurrent activity, small changes in the parameters or conditions can lead to runaway oscillations. Thus, the very changes that improve the processing performance of the network can put it at risk of runaway oscillation. To prevent this, stimulus-dependent network changes should be permitted only when there is a margin of safety around the current network parameters. We propose that the essential role of sleep is to establish this margin by exposing the network to a variety of inputs, monitoring for erratic behavior, and adjusting the parameters. When sleep is not possible, an emergency mechanism must come into play, preventing runaway behavior at the expense of processing efficiency. This is tiredness.
CAMBRIDGE
0899-7667
Grant Details