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Mandatory Fields
Reviews
Bernardi, A;Jimenez-Barbero, J;Casnati, A;De Castro, C;Darbre, T;Fieschi, F;Finne, J;Funken, H;Jaeger, KE;Lahmann, M;Lindhorst, TK;Marradi, M;Messner, P;Molinaro, A;Murphy, PV;Nativi, C;Oscarson, S;Penades, S;Peri, F;Pieters, RJ;Renaudet, O;Reymond, JL;Richichi, B;Rojo, J;Sansone, F;Schaffer, C;Turnbull, WB;Velasco-Torrijos, T;Vidal, S;Vincent, S;Wennekes, T;Zuilhof, H;Imberty, A
2013
January
Multivalent glycoconjugates as anti-pathogenic agents
Published
1
358 ()
Optional Fields
FIMBRIATED ESCHERICHIA-COLI LECTIN PA-IIL PROTEIN-CARBOHYDRATE INTERACTIONS PSEUDOMONAS-AERUGINOSA BIOFILMS DC-SIGN BACTERIAL LECTIN CHOLERA-TOXIN HIGH-AFFINITY STRUCTURAL BASIS GLYCOPEPTIDE DENDRIMERS
Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
CAMBRIDGE
ROYAL SOC CHEMISTRY
0306-0012
4709
4727
10.1039/c2cs35408j
Grant Details