Peer-Reviewed Journal Details
Mandatory Fields
Smith, A;Rowan, R;McCann, M;Kavanagh, K
2012
June
BioMetals
Exposure of Staphylococcus aureus to silver(I) induces a short term protective response
Published
5 ()
Optional Fields
PROTEOMIC ANALYSIS RESISTANCE PATHOGENICITY PROTEINS STRESS CELLS
25
611
616
The Ag(I) ion has well established anti-bacterial and antifungal properties. Exposure of to MIC80 AgNO3 (3 mu g/ml) lead to an increase in the activity of superoxide dismutase, glutathione reductase and catalase at 30 min but activity declined by 60 min. In addition, exposure of cells to this metal ion for 1 h lead to increased expression of a number of proteins such as elongation factors Ts, Tu and G, fructose-bisphosphate aldolase and triosephosphate isomerase but their expression declined following 4 h exposure. ATP binding cassette transporter protein and oligoendopeptidase F showed increased expression at 4 h. While Ag(I) is a potent antimicrobial agent this work demonstrates that can mount a short-term protective response to exposure to the metal ion but that this is eventually overcome.
DORDRECHT
0966-0844
10.1007/s10534-012-9549-3
Grant Details