Peer-Reviewed Journal Details
Mandatory Fields
Singh, I;Heaney, F
2010
January
Organic and Biomolecular Chemistry
Metal free, "click and click-click" conjugation of ribonucleosides and 2 '-OMe oligoribonucleotides on the solid phase
Published
17 ()
Optional Fields
1,3-DIPOLAR CYCLOADDITION TERMINAL ALKYNES IN-VIVO CHEMISTRY DNA DELIVERY OLIGONUCLEOTIDES NUCLEOSIDE STRATEGIES ANTISENSE
8
451
456
A fast and practical metal free conjugation of ribonucleosides and 2'-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3'- or the 5'-terminus of the oligoribonucleotide substrate.
CAMBRIDGE
1477-0520
10.1039/b918463e
Grant Details