Peer-Reviewed Journal Details
Mandatory Fields
Creaven, BS;Egan, DA;Kavanagh, K;McCann, M;Noble, A;Thati, B;Walsh, M
2006
September
Inorganica Chimica Acta
Synthesis, characterization and antimicrobial activity of a series of substituted coumarin-3-carboxylatosilver(I) complexes
Published
93 ()
Optional Fields
ACTIVATED PROTEIN-KINASE MALIGNANT MELANOMA-CELLS RENAL-CARCINOMA CELLS COUMARIN DERIVATIVES PHARMACOLOGICAL ACTIVITY CYTOTOXIC ACTIVITY BIS-COUMARINS ANALOGS CANCER 4-METHYL-7-HYDROXYCOUMARIN
359
3976
3984
A series of new coumarin-derived carboxylate ligands and their silver(l) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a clinical isolate of Candida albicans. The ligands were synthesised by either acid or base hydrolysis of their corresponding esters, which in turn were synthesised via the Knoevenegal reaction. The reaction of silver(I) nitrate with the coumarin carboxylate ligands in either aqueous or aqueous/ethanol solutions allowed the isolation of a series of novel Ag(I) carboxylate complexes. Whilst none of the ligands showed any antimicrobial activity, a number of the Ag(l) complexes exhibited potent activity, In particular, Ag(I) complexes of hydroxy-substituted coumarin carboxylates demonstrated potent activity against the clinically important methicillin-resistant Staphylococcus aureus (MRSA) bacterium (MIC80 = 0.63 mu M). (c) 2006 Elsevier B.V. All rights reserved.
LAUSANNE
0020-1693
10.1016/j.ica.2006.04.006
Grant Details