Peer-Reviewed Journal Details
Mandatory Fields
Sarikaya-Bayram O.;Bayram O.;Feussner K.;Kim J.;Kim H.;Kaever A.;Feussner I.;Chae K.;Han D.;Han K.;Braus G.
2014
May
Developmental Cell
Membrane-bound methyltransferase complex VapA-VipC-VapB guides epigenetic control of fungal development
Published
()
Optional Fields
29
4
406
420
Epigenetic and transcriptional control of gene expression must be coordinated in response to external signals to promote alternative multicellular developmental programs. The membrane-associated trimeric complex VapA-VipC-VapB controls a signal transduction pathway for fungal differentiation. The VipC-VapB methyltransferases are tethered to the membrane by the FYVE-like zinc finger protein VapA, allowing the nuclear VelB-VeA-LaeA complex to activate transcription for sexual development. Once the release from VapA is triggered, VipC-VapB is transported into the nucleus. VipC-VapB physically interacts with VeA and reduces its nuclear import and protein stability, thereby reducing the nuclear VelB-VeA-LaeA complex. Nuclear VapB methyltransferase diminishes the establishment of facultative heterochromatin by decreasing histone 3 lysine 9 trimethylation (H3K9me3). This favors activation of the regulatory genes brlA and abaA, which promote the asexual program. The VapA-VipC-VapB methyltransferase pathway combines control of nuclear import and stability of transcription factors with histone modification to foster appropriate differentiation responses. © 2014 Elsevier Inc.
1534-5807
10.1016/j.devcel.2014.03.020
Grant Details