Peer-Reviewed Journal Details
Mandatory Fields
Doyle S.;Shirey K.;McGettrick A.;Kenny E.;Carpenter S.;Caffrey B.;Gargan S.;Quinn S.;Caamaño J.;Moynagh P.;Vogel S.;Neill L.
2013
August
Journal of Biological Chemistry
Nuclear factor κb2 p52 protein has a role in antiviral immunity through IκB kinase ε-dependent induction of Sp1 protein and interleukin 15
Published
()
Optional Fields
288
35
25066
25075
Background: IKKε can promote the ability of p52 to transactivate gene expression in a manner requiring p65. Results: p52 is induced by TLR3 activation and regulates Sp1 transcription. Sp1 promotes the transcription of IL-15. Both events require the presence of IKKε and p52. Conclusion: p52 is a target for IKKε in antiviral immunity. Significance: This study reports a role for NFεB2 in the induction of antiviral gene expression. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
0021-9258
10.1074/jbc.M113.469122
Grant Details