Conference Publication Details
Mandatory Fields
García M.;Verwoerd M.;Pearlmutter B.;Wellstead P.;Middleton R.
Proceedings of the IEEE Conference on Decision and Control
Deep brain stimulation may reduce tremor by preferential blockade of slower axons via antidromic activation
2011
December
Published
1
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Optional Fields
6481
6486
Deep brain stimulation (DBS) has been used to ameliorate essential and Parkinsonian tremor, however the detailed mechanism by which tremor reduction is achieved remains unclear. We hypothesize that DBS works by reducing time delays in the feedback paths of the motor control loops. In particular, we suggest that antidromic activation of axonal pathways induced by stimulation will preferentially block axons with longer propagation times, reducing time delays in neuronal motor circuits in a stabilising manner. We demonstrate the plausibility of this hypothesis using two simple computational models which account for a variety of experimental results, and allow us to makes a number of testable predictions. © 2011 IEEE.
10.1109/CDC.2011.6160710
Grant Details