Peer-Reviewed Journal Details
Mandatory Fields
Algay V.;O'Sullivan J.;Heaney F.
2014
April
European Journal of Organic Chemistry
C-3β-tethered functional cholesterol conjugates by nitrile oxide alkyne cycloaddition (NOAC)
Published
()
Optional Fields
Alkynes Conjugation Cycloaddition Heterocycles Lipids Steroids
2014
12
2522
2532
Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol- biomolecule conjugates. Nitrile oxide alkyne cycloaddition (NOAC) chemistry - a tool for attaching cholesterol to biomolecules or groups capable of bioreporting. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
1434-193X
10.1002/ejoc.201301822
Grant Details