Peer-Reviewed Journal Details
Mandatory Fields
Elmes R.
2016
January
Chemical Communications
Bioreductive fluorescent imaging agents: Applications to tumour hypoxia
Published
59 ()
Optional Fields
52
58
8935
8956
© The Royal Society of Chemistry 2016.Large tumours contain regions with very low intracellular O2 concentrations. Known as hypoxia, this feature of tumours yields a highly reducing environment owing to the presence of numerous oxygen sensitive reductase enzymes. The development of new optical chemosensors for these various reductases presents an ideal approach to visualise areas of hypoxia or highly reducing environments. Critical to the success of such chemosensors is the design of probes containing a bioreductively activated moiety that either ensures the selective retention of fluorescence within a hypoxic tissue or a probe that irreversibly releases a reporter fluorophore. This Feature Article aims to summarise the fluorescent tools that have been developed to image tumour hypoxia and the various reductase enzymes associated with the bioreduction process.
1359-7345
10.1039/c6cc01037g
Grant Details