Peer-Reviewed Journal Details
Mandatory Fields
Carty, F;Mahon, BP;English, K
2017
April
Clinical and Experimental Immunology
The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?
Published
15 ()
Optional Fields
VERSUS-HOST-DISEASE ADULT PROGENITOR CELLS ALLERGIC AIRWAY INFLAMMATION REGULATORY T-CELLS ACUTE LUNG INJURY STEM-CELLS DENDRITIC CELLS MOUSE MODEL INDOLEAMINE 2,3-DIOXYGENASE EXTRACELLULAR VESICLES
188
1
11
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies. A complex cross-talk exists through which MSC and macrophages communicate, a communication that is not controlled exclusively by MSC. Here, we examine the evidence that suggests that MSC not only respond to inflammatory macrophages and adjust their secretome accordingly, but also that macrophages respond to encounters with MSC, creating a feedback loop which contributes to the immune regulation observed following MSC therapy. Future studies examining the effects of MSC on macrophages should consider the antagonistic role that macrophages play in this exchange.
HOBOKEN
0009-9104
10.1111/cei.12929
Grant Details