Peer-Reviewed Journal Details
Mandatory Fields
Boulenouar, S;Michelet, X;Duquette, D;Alvarez, D;Hogan, AE;Dold, C;O'Connor, D;Stutte, S;Tavakkoli, A;Winters, D;Exley, MA;O'Shea, D;Brenner, MB;von Andrian, U;Lynch, L
2017
February
Immunity
Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity
Published
2 ()
Optional Fields
NATURAL-KILLER-CELLS INVARIANT NKT CELLS INSULIN-RESISTANCE T-CELLS TISSUE MACROPHAGES OBESITY DIFFERENTIATION INFLAMMATION DIVERSITY PROMOTE
46
273
286
Adipose tissue has a dynamic immune system that adapts to changes in diet and maintains homeostatic tissue remodeling. Adipose type 1 innate lymphoid cells (AT1-ILCs) promote pro-inflammatory macrophages in obesity, but little is known about their functions at steady state. Here we found that human and murine adipose tissue harbor heterogeneous populations of AT1-ILCs. Experiments using parabiotic mice fed a high-fat diet (HFD) showed differential trafficking of AT1-ILCs, particularly in response to short-and long-term HFD and diet restriction. At steady state, AT1-ILCs displayed cytotoxic activity toward adipose tissue macrophages (ATMs). Depletion of AT1-ILCs and perforin deficiency resulted in alterations in the ratio of inflammatory to anti-inflammatory ATMs, and adoptive transfer of AT1-ILCs exacerbated metabolic disorder. Diet-induced obesity impaired AT1-ILC killing ability. Our findings reveal a role for AT1-ILCs in regulating ATM homeostasis through cytotoxicity and suggest that this function is relevant in both homeostasis and metabolic disease.
CAMBRIDGE
1074-7613
10.1016/j.immuni.2017.01.008
Grant Details