Peer-Reviewed Journal Details
Mandatory Fields
Hams, E;Bermingham, R;Wurlod, FA;Hogan, AE;O'Shea, D;Preston, RJ;Rodewald, HR;McKenzie, ANJ;Fallon, PG
2016
February
FASEB Journal
The helminth T2 RNase omega 1 promotes metabolic homeostasis in an IL-33-and group 2 innate lymphoid cell-dependent mechanism
Published
5 ()
Optional Fields
SCHISTOSOMA-MANSONI EGGS ADIPOSE-TISSUE INFLAMMATION ALTERNATIVELY ACTIVATED MACROPHAGES MANNOSE RECEPTOR TH2 POLARIZATION CUTTING EDGE BEIGE FAT TYPE-2 MICE OBESITY
30
824
835
Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived v1 (v1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activated macrophages in the adipose tissue. IL-33 release from cells in the adipose tissue is mediated by the RNase activity of v1; however, the ability of v1 to improve metabolic status is reliant upon effective binding of v1 to CD206. We demonstrate a novel mechanism for RNase-mediated release of IL-33 inducing ILC2-dependent improvements in the metabolic status of obese animals.
BETHESDA
0892-6638
10.1096/fj.15-277822
Grant Details