Peer-Reviewed Journal Details
Mandatory Fields
Barrett S.;Delaney S.;Kavanagh K.;Montagner D.
2018
July
Inorganica Chimica Acta
Evaluation of in vitro and in vivo antibacterial activity of novel Cu(II)-steroid complexes
Published
2 ()
Optional Fields
Antimicrobial Copper(II) In vivo Phenanthroline Steroids
479
261
265
© 2018 Elsevier B.V. A pioneer series of copper(II) complexes bearing planar phenanthroline-modified aromatic ligands and steroid (ethynylestradiol and ethisterone) with generic formula [Cu(N ∩ N)(steroid)](NO3)2where N ∩ N is DPQ, DPPZ and DPPN and steroid is estradiol or testosterone, were synthetized, characterised and screened in vitro and in vivo as antimicrobial agents against Staphylococcus aureus and methicillin resistant Staphylococcus aureus (MRSA). Toxicity studies revealed notable antibacterial activity of the copper – based compounds, which is significantly increased in vivo by the presence of the steroid moiety. Toxicity profiling was estimated in vitro versus Gram-positive (Staphylococcus aureus) and MRSA and in vivo in Galleria mellonella larvae infected with S. aureus. Results showed the complexes to be active against S. aureus and MRSA in vitro (MIC50average value of 2.46 and 97 μM in S. aureus and MRSA, respectively) and to be active when larvae infected with S. aureus were administered the agents.
0020-1693
10.1016/j.ica.2018.04.054
Grant Details