Peer-Reviewed Journal Details
Mandatory Fields
O'Flaherty R.;Velasco-Torrijos T.
2018
April
Synlett
Glycosylated α-Azido Amino Acids: Versatile Intermediates in the Synthesis of Neoglycoconjugates
Published
2 ()
Optional Fields
CuAAC reaction glycosylation neoglycoconjugates 1,2,3-triazolyl glycosides α-azido amino acid
29
7
904
907
© Georg Thieme Verlag Stuttgart New York. A series of glycosylated α-azido amino acids was synthesized as precursors for neoglycoconjugates, a class of important biomolecules for drug discovery, and sensor development. The synthetically challenging 1,2- cis α-galactosylated species described herein were designed as building blocks in the synthesis of analogues of α-galactosyl ceramide, a potent immunomodulator. A benzyl-protected 1,2,3-triazolyl α-galactosyl- l -serine derivative was prepared using copper azide alkyne cycloaddition to showcase the potential of glycosylated α-azido amino acids in neoglycoconjugate design.
0936-5214
10.1055/s-0036-1591902
Grant Details