Peer-Reviewed Journal Details
Mandatory Fields
Robinson MW;McGuinness D;Swann R;Barclay S;Mills PR;Patel AH;McLauchlan J;Shiels PG;
2013
December
Aging Cell
Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease.
Published
()
Optional Fields
12
6
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as a biomarker of aging (BoA). In this study, we have evaluated CDKN2 locus transcripts as alternative BoAs in C-HC. Our results suggest that C-HC induces non-cell-autonomous senescence and accelerates biological aging. The CDKN2 locus may provide a link between C-HC and increased susceptibility to age-associated diseases and provides novel biomarkers for assessing its impact on aging processes in man.
1474-9726
10.1111/acel.12125
Grant Details