Peer-Reviewed Journal Details
Mandatory Fields
Ahmed M;Rooney D;McCann M;Casey J;O'Shea K;Twamley B;
2019
October
Dalton Transactions
Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands.
Published
0 ()
Optional Fields
48
40
Pyrido-phenanthrolin-7-one compounds are structural analogues of the cytotoxic alkaloid, ascididemin, and would be expected to have interesting biological activities. Synthetic strategies are reported for a novel simple route to form this class of ligand. 1,10-Phenanthrolin-5,6-dione reacts with l-phenylalanine alkyl esters and their para-substituted analogues to form both a phenanthroline-oxazine and a pyrido-phenanthrolin-7-one product. The nature of the major product is dependent on the electronic properties of the para substituent. Successful metal coordination to the pyrido-phenanthrolin-7-one ligand is also presented.
1477-9234
10.1039/c9dt03084k
Grant Details